AL amyloidosis neuropathy
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
AL amyloidosis neuropathy. This is a paraproteinaemic neuropathy. The mean onset age is 65 years. Fully referenced neurology checklist.
Demographic features
- This is a paraproteinaemic neuropathy
- The mean onset age is 65 years
- Males account for two-thirds of cases
- It rapidly progresses from small to large fiber neuropathy
Neuropathy presentations
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Other neurological presentations
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Clinical features
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Non-neurological features
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Treatment
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Investigational treatment
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References
- Murphy S, Reilly M. Amyloid neuropathies. ACNR 2011; 11:16-19.
- Wang AK, Fealey RD, Gehrking TL, Low PA. Patterns of neuropathy and autonomic failure in patients with amyloidosis. Mayo Clin Proc 2008; 83:1226-1230.
- Kowalewski-Zietek J, Dawson TP, Damodaron D, Gillmore JD. An unusual cause of carpal tunnel syndrome. Pract Neurol 2011; 11:352-354.
- Matsuda M, Gono T, Morita H, Katoh N, Kodaira M, Ikeda S. Peripheral nerve involvement in primary systemic AL amyloidosis: a clinical and electrophysiological study. Eur J Neurol 2011; 18:604-610.
- Thimm A, Carpinteiro A, Oubari S, et al. Prevalence and predictors of neurological manifestations in systemic AL amyloidosis. J Neurol Sci 2022; 440:120341.
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