Amyloid myopathy: management

Evidence-based neurology checklist on amyloid myopathy: management: Blood and urine tests Creatinine kinase (CK): this is normal in 50% of cases Cardiac troponin T: this is elevated without heart disease Free light chains in serum and urine Magnetic resonance imaging (MRI) muscle Muscle biopsy:…

Blood and urine tests

  • Creatinine kinase (CK): this is normal in 50% of cases
  • Cardiac troponin T: this is elevated without heart disease
  • Free light chains in serum and urine

Magnetic resonance imaging (MRI) muscle

Muscle biopsy: features

Other biopsies for amyloid myopathy

Test for amyloidosis

Treatment

References

  1. Muchtar E, Derudas D, Mauermann M, et al. Systemic immunoglobulin light chain amyloidosis-associated myopathy: presentation, diagnostic pitfalls, and outcome. Mayo Clin Proc 2016; 91:1354-1361.
  2. Gertz MA, Kyle RA. Myopathy in primary systemic amyloidosis. JNNP 1996; 60:655-660.
  3. Hull KM, Griffith L, Kuncl RW, Wigley FM. A deceptive case of amyloid myopathy: clinical and magnetic resonance imaging features. Arthritis Rheum 2001; 44:1954-1958.
  4. Metzler JP, Fleckenstein JL, White CL 3rd, Haller RG, Frenkel EP, Greenlee RG Jr. MRI evaluation of amyloid myopathy. Skeletal Radiol 1992; 21:463-465.
  5. Okamoto K, Ito J, Emura I, Kawasaki T, Furusawa T, Sakai K, Tokiguchi S. Focal orbital amyloidosis presenting as rectus muscle enlargement: CT and MR findings. Am J Neuroradiol 1998; 19:1799-1801.
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