Anti-MOG antibody disease (MOGAD): course and outcome

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Anti-MOG antibody disease (MOGAD): course and outcome. Optic neuritis (ON) onset, Transverse myelitis (TM) onset. Fully referenced neurology checklist.

Onset types

  • Optic neuritis (ON) onset
  • Transverse myelitis (TM) onset
  • Pure brain symptoms onset
  • Combined ON and TM onset

Course types

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Complications

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Risk factors for relapse

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Course in pregnancy

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Misdiagnosis: causes of false positive anti MOG antibody test

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Red flags against anti-MOG antibody disorder

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Acronym

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References

  1. Jarius S, Ruprecht K, Kleiter I, et al; in cooperation with the Neuromyelitis Optica Study Group (NEMOS). MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome. J Neuroinflammation 2016; 13:280.
  2. Jarius S, Kleiter I, Ruprecht K, et al; in cooperation with the Neuromyelitis Optica Study Group (NEMOS). MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 3: Brainstem involvement - frequency, presentation and outcome. J Neuroinflammation 2016; 13:281.
  3. Zhou Y, Jia X, Yang H, et al. Myelin oligodendrocyte glycoprotein antibody-associated demyelination: comparison between onset phenotypes. Eur J Neurol 2019; 26:175-183.  
  4. Fadda G, Banwell B, Waters P, et al. Silent new brain MRI lesions in children with MOG-antibody associated disease. Ann Neurol 2020 (Online ahead of print).
  5. Oliveira LM, Apóstolos-Pereira SL, Pitombeira MS, Bruel Torretta PH, Callegaro D, Sato DK. Persistent MOG-IgG positivity is a predictor of recurrence in MOG-IgG-associated optic neuritis, encephalitis and myelitis. Mult Scler 2018; 12:1352458518811597.
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