Anti-MOG antibody disease (MOGAD): MRI features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Anti-MOG antibody disease (MOGAD): MRI features. Longitudinally extensive transverse myelitis (LETM). Fully referenced neurology checklist.
Spinal cord features (myelitis)
- Longitudinally extensive transverse myelitis (LETM)
- Longitudinally extensive spinal cord atrophy
- Conus medullaris lesions: at disease onset
- The spinal H sign
- The MRI may be normal
Optic nerve features
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Cerebral hemisphere features
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Absent features which differentiate from multiple sclerosis (MS)
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Radiological differentials
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References
- Jarius S, Paul F, Aktas O, et al. MOG encephalomyelitis: international recommendations on diagnosis and antibody testing. J Neuroinflammation 2018; 15:134.
- Symmonds M, Waters PJ, Küker W, Leite MI, Schulz UG. Anti-MOG antibodies with longitudinally extensive transverse myelitis preceded by CLIPPERS. Neurology 2015; 84:1177-1179.
- Abdulla MC. Myelin oligodendrocytes glycoprotein antibody-positive longitudinally extensive myelitis with owl's eye sign mimicking acute anterior spinal artery Ischemia. Ann Indian Acad Neurol 2022; 25:931-932.
- Sahoo D, Dash A, Dey A, Devi S. Myelin oligodendrocyte glycoprotein (MOG) antibody-associated longitudinally extensive transverse myelitis (LETM) and primary Sjogren syndrome: a rare association. BMJ Case Rep 2022; 15:e249915.
- Ortiz SA, Perilla LAC, Capera APG. The "H sign" in MOGAD myelitis. Neurol Sci 2025; 46:4771-4772.
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