Bing-Neel syndrome (BNS)
Evidence-based neurology checklist on bing-neel syndrome (bns): Pathology This is central nervous system involvement by Waldenstrom’s macroglobulinaemia (WM) It results from infiltration by malignant lymphoid cells It is the first manifestation of WM in more than a third of cases Central features…
Pathology
- This is central nervous system involvement by Waldenstrom’s macroglobulinaemia (WM)
- It results from infiltration by malignant lymphoid cells
- It is the first manifestation of WM in more than a third of cases
Central features
Ophthalmic features
Peripheral features
Differential diagnosis
Magnetic resonance imaging (MRI) brain
Cerebrospinal fluid (CSF) analysis
Other investigations
Treatment
Prognosis
References
- Simon L, Fitsiori A, Lemal R, et al. Bing-Neel syndrome, a rare complication of Waldenström macroglobulinemia: analysis of 44 cases and review of the literature. A study on behalf of the French Innovative Leukemia Organization (FILO). Haematologica 2015; 100:1587-1594.
- Varettoni M, Defrancesco I, Diamanti L, Marchioni E, Farina LM, Pichiecchio A. Bing-Neel syndrome: illustrative cases and comprehensive review of the literature. Mediterr J Hematol Infect Dis 2017; 9:e2017061.
- Bhatti MT, Yuan C, Winter W, McSwain AS, Okun MS. Bilateral sixth nerve paresis in the Bing-Neel syndrome. Neurology 2005; 64:576-577.
- Welch D, Whetsell WO Jr, Weil RJ. Pathologic quiz case. A man with long-standing monoclonal gammopathy and new onset of confusion. Central nervous system involvement by Waldenström macroglobulinemia-Bing-Neel syndrome. Arch Pathol Lab Med 2002; 126:1243-1244.
- Sobczak T, Alleman L, Wille H, et al. Recurrent meningitis revealing a Bing-Neel syndrome. Rev Med Interne 2021; 42:359-362.
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