Cerebral amyloid angiopathy (CAA): treatment

Evidence-based neurology checklist on cerebral amyloid angiopathy (caa): treatment: Preventative treatment of haemorrhage Intensive care unit for initial management Avoid straining: this increases the risk of bleeding Venous thrombosis prophylaxis Maintain normoglycaemia Treatment of associated…

Preventative treatment of haemorrhage

  • Intensive care unit for initial management
  • Avoid straining: this increases the risk of bleeding
  • Venous thrombosis prophylaxis
  • Maintain normoglycaemia

Treatment of associated coagulopathy

Treatments to limit haematoma expansion

Other treatments

Investigational treatments

References

  1. Mehndiratta P, Manjila S, Ostergard T, Eisele S, Cohen ML, Sila C, Selman WR. Cerebral amyloid angiopathy-associated intracerebral hemorrhage: pathology and management. Neurosurg Focus 2012; 32:E7.
  2. Charidimou A, Gang Q, Werring DJ. Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum. JNNP 2012; 83:124-137.
  3. Regenhardt RW, Thon JM, Das AS, et al. Association between immunosuppressive treatment and outcomes of cerebral amyloid angiopathy-related inflammation. JAMA Neurol 2020; 77:1261-1269.
  4. Snorradottir AO, Gutierrez-Uzquiza A, Bragado P, et al. N-acetylcysteine for hereditary cystatin C amyloid angiopathy: a nonrandomized clinical trial. JAMA Neurol 2025; 82:486-494.
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