Cerebral malaria: investigations
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Cerebral malaria: investigations. Blood glucose, Acidosis, Blood film: thick and thin, Microscopy. Fully referenced neurology checklist.
Blood investigations
- Blood glucose
- Acidosis
- Blood film: thick and thin
- Microscopy
- Polymerase chain reaction (PCR): this is more sensitive than microscopy
Emerging biomarkers
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Computed tomography (CT) head: features
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Magnetic resonance imaging (MRI) brain
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Other investigations
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Emerging ophthalmologic investigations
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References
- Idro R, Jenkins NE, Newton CR. Pathogenesis, clinical features, and neurological outcome of cerebral malaria. Lancet Neurol 2005; 4:827-840.
- Newton CR, Hien TT, White N. Cerebral malaria. JNNP 2000; 69:433-441.
- Lucchi NW, Jain V, Wilson NO, Singh N, Udhayakumar V, Stiles JK. Potential serological biomarkers of cerebral malaria. Dis Markers 2011; 31:327-335.
- Lovegrove FE, Tangpukdee N, Opoka RO, et al. Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children. PLoS One 2009; 4: e4912.
- Jain V, Lucchi NW, Wilson NO, et al. Plasma levels of angiopoietin-1 and -2 predict cerebral malaria outcome in Central India. Malar J 2011; 10:383.
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