CGRP receptor antagonists (CGRP-RAs): general aspects
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
CGRP receptor antagonists (CGRP-RAs): general aspects. α- CGRP: this is the conventional CGRP, β-CGRP. Fully referenced neurology checklist.
CGRP gene family members
- α- CGRP: this is the conventional CGRP
- β-CGRP
- Adrenomedullin
- Adrenomedullin 2
- Amylin
- Calcitonin
CGRP receptor subunits
Locked: subscribe to see this section.
CGRP role in migraine pathogenesis
Locked: subscribe to see this section.
Approved CGRP-RAs
Locked: subscribe to see this section.
Investigational intranasal CGRP-RAs
Locked: subscribe to see this section.
Indications
Locked: subscribe to see this section.
Discontinued CGRP-RAs
Locked: subscribe to see this section.
Re-starting after discontinuation
Locked: subscribe to see this section.
Synonym
Locked: subscribe to see this section.
References
- Russo AF. Calcitonin gene-related peptide (CGRP): a new target for migraine. Annu Rev Pharmacol Toxicol 2015; 55:533-552.
- Voss T, Lipton RB, Dodick DW, et al. A phase IIb randomized, double-blind, placebo-controlled trial of ubrogepant for the acute treatment of migraine. Cephalalgia 2016; 36:887-898.
- Scott LJ. Rimegepant: first approval. Drugs 2020; 80:741-746.
- Kish T. Emerging therapies for patients with difficult-to-treat migraine. P T 2018; 43:616-621.
- Croop R, Madonia J, Stock DA, et al. Zavegepant nasal spray for the acute treatment of migraine: a Phase 2/3 double-blind, randomized, placebo-controlled, dose-ranging trial. Headache 2022; 62:1153-1163.
- And 6 more. Subscribe to see the full list
