Chronic granulomatous herpes simplex encephalitis
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Chronic granulomatous herpes simplex encephalitis. This usually occurs in children: but it may affect adults. Fully referenced neurology checklist.
Demographic features and pathogenesis
- This usually occurs in children: but it may affect adults
- It is usually biphasic following the initial herpes infection
- It may be related to toll-like receptor 3 (TLR-3) deficiency
Clinical features
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Pathological features
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Differential diagnosis
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Treatment
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References
- Schutz PW, Fauth CT, Al-Rawahi GN, et al. Granulomatous herpes simplex encephalitis in an infant with multicystic encephalopathy: a distinct clinicopathologic entity? Pediatr Neurol 2014; 50:392-396.
- Varatharaj A, Nicoll JA, Pelosi E, Pinto AA. Corticosteroid-responsive focal granulomatous herpes simplex type-1 encephalitis in adults. Pract Neurol 2017; 17:140-144.
- Viñas JM, Gonzalez MJ, Ribes AG, Expósito RG, Bragado FG. Postencephalitic chronic granulomatous disease. Pediatr Neurol 2006; 35:297-299.
- Adamo MA, Abraham L, Pollack IF. Chronic granulomatous herpes encephalitis: a rare entity posing a diagnostic challenge. J Neurosurg Pediatr 2011; 8:402-406.
- Hackney JR, Harrison DK, Rozzelle C, et al. Chronic granulomatous herpes encephalitis in a child with clinically intractable epilepsy. Case Rep Pediatr 2012; 2012:849812.
