Chronic inflammatory axonal polyneuropathy (CIAP)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Chronic inflammatory axonal polyneuropathy (CIAP). Acquired, chronic progressive or relapsing polyneuropathy. Fully referenced neurology checklist.
Diagnostic criteria
- Acquired, chronic progressive or relapsing polyneuropathy
- It is symmetrical or asymmetrical
- There is progression over >2 months
- There is electrophysiological evidence of axonal neuropathy in at least two nerves
- There are no clear features of demyelination
- There is responsiveness to immunotherapy
Triggers: 4-8 weeks before onset
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Major clinical features
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Rarer clinical features
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Associated disorders
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Investigations
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Treatment
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References
- Oh SJ, Lu L, Alsharabati M, Morgan MB, King P. Chronic inflammatory axonal polyneuropathy. JNNP 2020; 91:1175-1180.
- Luca A, Squillaci R, Terravecchia C, et al. Pure sensitive chronic inflammatory polyneuropathy following Pfizer COVID-19 vaccine. Neurol Sci 2021 (Online ahead of print).
- Ragavendar B, Sugumaran R, Narayan SK, Srinivas BH. Chronic inflammatory axonal polyneuropathy with myositis: a rare presentation. Acta Neurol Belg 2023 (Online ahead of print).
- Uncini A, Sabatelli M, Mignogna T, Lugaresi A, Liguori R, Montagna P. Chronic progressive steroid responsive axonal polyneuropathy: a CIDP vaariant or a primary axonal disorder? Muscle Nerve 1996; 19:365-371.
- Chroni E, Hall SM, Hughes RA. Chronic relapsing axonal neuropathy: a first case report. Ann Neurol 1995; 37:112-115.
