Eosinophilic granulomatosis with polyangiitis (EGPA): management

Evidence-based neurology checklist on eosinophilic granulomatosis with polyangiitis (egpa): management: Blood tests Peripheral eosinophilia P-ANCA anti-myeloperoxidase (MPO) C-reactive protein (CRP): this may be elevated IgG4 Histological tests Other tests Treatment Emerging treatments Synonym

Blood tests

  • Peripheral eosinophilia
  • P-ANCA anti-myeloperoxidase (MPO)
  • C-reactive protein (CRP): this may be elevated
  • IgG4

Histological tests

Other tests

Treatment

Emerging treatments

Synonym

References

  1. Gioffredi A, Maritati F, Oliva E, Buzio C. Eosinophilic granulomatosis with polyangiitis: an overview. Front Immunol 2014; 5:549.
  2. Uematsu H, Takata S, Sueishi K, Inoue H. Polyangiitis overlap syndrome of granulomatosis with polyangiitis (Wegener's granulomatosis) and eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). BMJ Case Rep 2014; 2014:bcr2013010195.
  3. Masuda Y, Matsuda S, Okazaki A, et al. Clinical features and prognosis of EGPA-associated peripheral neuropathy: a multicentre REVEAL cohort study. J Neurol 2026; 273:641.
  4. Quan MV, Frankel SK, Maleki-Fischbach M, Tan LD. A rare case report of polyangiitis overlap syndrome: granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis. BMC Pulm Med 2018; 18:181.
  5. Cottin V, Bel E, Bottero P, et al. Revisiting the systemic vasculitis in eosinophilic granulomatosis with polyangiitis (Churg-Strauss): A study of 157 patients by the Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires and the European Respiratory Society Taskforce on eosinophilic granulomatosis with polyangiitis (Churg-Strauss). Autoimmun Rev 2017; 16:1-9.
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