Germ cell tumours: clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Germ cell tumours: clinical features. The onset age is 0-20 years with non-germinomas. Fully referenced neurology checklist.
Onset age
- The onset age is 0-20 years with non-germinomas
- The range is 7-30 years with germinomas
Frequent sites
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Features of raised intracranial pressure (ICP)
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Visual features
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Cranial nerve palsies
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Motor features
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Endocrine features
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Psychiatric features
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Other features
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References
- Borde TD, Arimappamagan A, Srinivas D, et al. Intracranial germ cell tumors: spectrum of disease in an Indian cohort and management strategies. J Neurosci Rural Pract 2018; 9:291-297.
- Echevarría ME, Fangusaro J, Goldman S. Pediatric central nervous system germ cell tumors: a review. Oncologist 2008; 13:690-699.
- Aihara Y, Watanabe S, Amano K, et al. Placental alkaline phosphatase levels in cerebrospinal fluid can have a decisive role in the differential diagnosis of intracranial germ cell tumors. J Neurosurg 2018; doi: 10.3171/2018.3.JNS172520 (Epub ahead of print).
- Tso WW, Yung AW, Lau HY, Chan GC. Basal ganglia germinoma: MRI classification correlates well with neurological and cognitive outcome. J Pediatr Hematol Oncol 2014; 36:e443-e447.
- Malbari F, Gershon TR, Garvin JH, Allen JC, Khakoo Y, Levy AS, Dunkel IJ. Psychiatric manifestations as initial presentation for pediatric CNS germ cell tumors, a case series. Childs Nerv Syst 2016; 32:1359-1362.
