Haematopoietic stem cell transplantation (HSCT)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Haematopoietic stem cell transplantation (HSCT). HSCT resets the immune system. Fully referenced neurology checklist.
Benefits
- HSCT resets the immune system
- About 70-80% of recipients are stabilised for 3-5 years
- The 10-year remission is about 70%
- It improves the quality of life
- It also improves functional scores
- It may be more effective than other immunosuppressive treatments
Indications
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Pre-procedure treatments
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HSC harvesting
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Conditioning chemotherapy options
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Infection-related side effects
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Other side effects
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Outcome
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Predictors of good outcome
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References
- Rogojan C, Frederiksen JL. Hematopoietic stem cell transplantation in multiple sclerosis. Acta Neurol Scand 2009; 120:371-382.
- Burman J, Iacobaeus E, Svenningsson A, et al. Autologous haematopoietic stem cell transplantation for aggressive multiple sclerosis: the Swedish experience. JNNP 2014; 85:1116-1121.
- Nash RA, Hutton GJ, Racke MK, et al. High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for relapsing-remitting multiple sclerosis (HALT-MS)A 3-year interim report. JAMA Neurol 2015; 72:159-169.
- Muraro PA, Martin R, Mancardi GL, Nicholas R, Sormani MP, Saccardi R. Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis. Nat Rev Neurol 2017; 13:391-405.
- Boffa G, Massacesi L, Inglese M, et al. Long-term clinical outcomes of hematopoietic stem cell transplantation in multiple sclerosis. Neurology 2021 (Online ahead of print).
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