Human herpes virus 6 (HHV-6) infection: post-transplant limbic encephalitis (PALE)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Human herpes virus 6 (HHV-6) infection: post-transplant limbic encephalitis (PALE). This follows hematopoietic stem cell transplantation (HSCT).
Pathology
- This follows hematopoietic stem cell transplantation (HSCT)
- The onset is 2-6 weeks after transplant
- It may be associated with delayed engraftment
Risk factors
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Neurological features
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Systemic features
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Complications
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Poor prognostic factors
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Magnetic resonance imaging (MRI) brain
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Other investigations
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Treatment
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Prevention
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Acronym
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References
- Berzero G, Campanini G, Vegezzi E, et al. Human herpesvirus 6 encephalitis in immunocompetent and immunocompromised hosts. Neurol Neuroimmunol Neuroinflamm 2021; 8:e942.
- Berger JR. Learning more about HHV-6 encephalitis. Neurol Neuroimmunol Neuroinflamm 2021 (online ahead of print).
- Bhanushali MJ, Kranick SM, Freeman AF, et al. Human herpes 6 virus encephalitis complicating allogeneic hematopoietic stem cell transplantation. Neurology 2013; 80:1494-1500.
- Ogata M, Fukuda T, Teshima T. Human herpesvirus-6 encephalitis after allogeneic hematopoietic cell transplantation: what we do and do not know. Bone Marrow Transplant 2015; 50:1030-1036.
- Miyashita N, Endo T, Onozawa M, et al. Risk factors of human herpesvirus 6 encephalitis/myelitis after allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis 2017 (online ahead of print).
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