Huntington’s disease (HD): clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Huntington’s disease (HD): clinical features. Personality change, Apathy, Anxiety, Depression, Irritability. Fully referenced neurology checklist.
Psychiatric features
- Personality change
- Apathy
- Anxiety
- Depression
- Irritability
- Aggressiveness
- Obsessive-compulsive behaviours
- Dysphoria
- Agitation
- Disinhibition
- Delusions
- Psychosis
- Suicidal ideations
Cognitive features
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Movement disorders
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Oculomotor disorders
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Other neurological features
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Systemic features
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Poor prognostic factors
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References
- van Duijn E, Craufurd D, Hubers AA, et al. Neuropsychiatric symptoms in a European Huntington's disease cohort (REGISTRY). JNNP 2014; 85:1411-1418.
- Paulsen JS, Ready RE, Hamilton JM, Mega MS, Cummings JL. Neuropsychiatric aspects of Huntington’s disease. JNNP 2001; 71:310–314.
- Novak MJU, Sarah J Tabrizi SJ. Huntington’s disease. BMJ 2010; 340:c3109.
- Rodríguez Santana I, Frank SA, Mestre TA, et al. Suicidal ideation and sleep disturbances among people with Huntington disease: evidence from the HDBOI Study. Neurol Clin Pract 2025; 15:e200461.
- Henley SM, Novak MJ, Frost C, King J, Tabrizi SJ, Warren JD. Emotion recognition in Huntington's disease: a systematic review. Neurosci Biobehav Rev 2012; 36:237-253.
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