IgG4-related disease: peripheral and systemic features

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

IgG4-related disease: peripheral and systemic features. Anti contactin (CNTN), Anti neurofascin 155 (NF155). Fully referenced neurology checklist.

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): antibodies

  • Anti contactin (CNTN)
  • Anti neurofascin 155 (NF155)
  • Anti Caspr1

Other peripheral neurological features

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Urogenital features

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Gastrointestinal features

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Allergic features

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Cardiorespiratory features

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Other systemic features

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References

  1. Huijbers MG, Querol LA, Niks EH, et al. The expanding field of IgG4-mediated neurological autoimmune disorders. Eur J Neurol 2015; 22:1151-1161.
  2. Dalmau J. Name a brain protein, and an autoantibody shall be found! Neurol Neuroimmunol Neuroinflamm 2015; 2:e159.
  3. Massey J. IgG4-related hypertrophic pachymeningitis coexpressing antineutrophil cytoplasmic antibodies. Neurol Neuroimmunol Neuroinflamm. 2017; 4:e341.
  4. AbdelRazek MA, Venna N, Stone JH. IgG4-related disease of the central and peripheral nervous systems. Lancet Neurol 2018; 17:183-192. 
  5. Joshi D, Jager R, Hurel S, et al. Cerebral involvement in IgG4-related disease. Clin Med (Lond) 2015; 15:130-134.
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