Lambert Eaton myasthenic syndrome (LEMS): variants

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Lambert Eaton myasthenic syndrome (LEMS): variants. This is associated with pulmonary and extra-pulmonary small cell cancer. It manifests as ataxia.

Paraneoplastic cerebellar degeneration with LEMS (PCD-LEMS)

  • This is associated with pulmonary and extra-pulmonary small cell cancer
  • It manifests as ataxia
  • The P/Q-type VGCC antibodies are present in most cases
  • GRP78 antibodies also play a role

LEMS-myasthenia gravis overlap syndrome

Locked: subscribe to see this section.

Genetic LEMS

Locked: subscribe to see this section.

Acronyms

Locked: subscribe to see this section.

References

  1. Kitanosono H, Motomura M, Tomita H, et al. Paraneoplastic cerebellar degeneration with Lambert-Eaton myasthenic syndrome: a report of an effectively treated case and systematic review of Japanese cases. Brain Nerve 2019; 71:167-174.
  2. Zalewski N, Lennon VA, Pittock SJ, Mckeon A. Calcium channel autoimmunity: Cerebellar ataxia and lambert-eaton syndrome coexisting. Muscle Nerve 2017; doi: 10.1002/mus.26053 (Epub ahead of print).
  3. McKasson M, Clardy SL, Clawson SA, et al. Voltage-gated calcium channel autoimmune cerebellar degeneration: case and study of cytotoxicity. Neurol Neuroimmunol Neuroinflamm 2016; 3:e222.
  4. Shimizu F, Takeshita Y, Sano Y, et al. GRP78 antibodies damage the blood-brain barrier and relate to cerebellar degeneration in Lambert-Eaton myasthenic syndrome. Brain 2019; 142:2253-2264.
  5. Takasugi J, Shimamura M, Koda T, et al. Paraneoplastic cerebellar degeneration and Lambert-Eaton Myasthenic Syndrome associated with neuroendocrine carcinoma of the oropharynx. Intern Med 2018; 57:587-590.
  6. And 4 more. Subscribe to see the full list

Related checklists

Loading...