Malformations of cortical development (MCD): classification

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Malformations of cortical development (MCD): classification. IA: Microcephaly, IB: Megalencephalies. Fully referenced neurology checklist.

Group I: disorders of abnormal neuronal and glial proliferation

  • IA: Microcephaly
  • IB: Megalencephalies
  • IC: Cortical dysgenesis with abnormal cell proliferation

Group II: disorders of neuronal migration

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Group III: disorders of abnormal post-migrational development

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Newer disorders

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References

  1. Barkovich AJ, Guerrini R, Kuzniecky RI, Jackson GD, Dobyns WB. A developmental and genetic classification for malformations of cortical development: update 2012. Brain 2012; 135:1348-1369.
  2. Bahi-Buisson N, Poirier K, Fourniol F, et al. The wide spectrum of tubulinopathies: what are the key features for the diagnosis? Brain 2014; 137:1676-1700.
  3. Barkovich AJ, Guerrini R, Kuzniecky RI, Jackson GD, Dobyns WB. A developmental and genetic classification for malformations of cortical development: update 2012. Brain 2012; 135:1348-1369.
  4. Arizono E, Tanei ZI, Iijima K, et al. MRI detection of mild malformation of cortical development with oligodendroglial hyperplasia (MOGHE) on T1WI-CHESS. Epilepsy Behav Rep 2024; 26:100674.
  5. Metodiev D, Minkin K, Dimova P, et al. Mild malformation of cortical development with oligodendroglial hyperplasia in frontal lobe epilepsy (MOGHE): a report of the first case in Bulgaria. Folia Neuropathol 2024 (Online ahead of print).

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