Melkersson Rosenthal syndrome

Cardinal features

• Recurrent non-pitting orofacial oedema
• Fissured tongue (lingua plicata)
• Recurrent lower motor neurone facial palsy
• The features may be unilateral or bilateral

Possible causes

Possible associated disorders

Associated features

Biopsy features of granulomatous cheilitis

Main treatments

Treatments based on case reports

References

1. Greene RM, Rogers RS 3rd. Melkersson-Rosenthal syndrome: A review of 36 patients. J Am Acad Dermatol 1989; 21:1263-1270.
2. Pimentel S, Mendes A, Rosas MJ. Peripheral facial palsy in the setting of Melkersson-Rosenthal Syndrome-case report. Rev Neurocienc 2012; 20:233-235.
3. Pisanty S, Sharav Y. The Melkersson-Rosenthal syndrome. Oral Surg 1969; 27:729-733.
4. Cockerham KP, Hidayat AA, Cockerham GC, et al. Melkersson-Rosenthal Syndrome: new clinicopathologic find­ings in 4 Cases. Arch Ophthalmol 2000; 118:227-232.
5. Pei Y, Beaman GM, Mansfield D, Clayton-Smith J, Stewart M, Newman WG. Clinical and genetic heterogeneity in Melkersson-Rosenthal Syndrome. Eur J Med Genet 2019; 62:103536. 
6. And 16 more. Subscribe to see the full list

Related checklists

• Ramsay Hunt syndrome (RHS)
• Post herpetic neuralgia (PHN)
• Gasperini syndrome
• Babinski sign of hemifacial spasm