Mitochondrial diseases: specific treatments
Evidence-based neurology checklist on mitochondrial diseases: specific treatments: Metabolic treatments Ubiquinone (co-enzyme Q10) 100mg tds L-carnitine Creatine monohydrate Alpha lipoic acid Vitamin C Vitamin K Folinic acid: for central folate deficiency in KSS Bicarbonate: for lactic acidosis…
Metabolic treatments
- Ubiquinone (co-enzyme Q10) 100mg tds
- L-carnitine
- Creatine monohydrate
- Alpha lipoic acid
- Vitamin C
- Vitamin K
- Folinic acid: for central folate deficiency in KSS
- Bicarbonate: for lactic acidosis
- Dichloroacetate: for lactic acidosis but it is neurotoxic
L-Arginine
Treatments of MNGIE
Other specific treatments
Other treatments
Supplements
Investigational treatments
Acronyms
References
- McFarland R, Turnbull DM. Batteries not included: diagnosis and management of mitochondrial disease. J Intern Med 2009; 265:210-228.
- McFarland R, Taylor RW, Turnbull DM. A neurological perspective on mitochondrial disease. Lancet Neurol 2010; 9:829-840.
- Rahman S, Hanna MG. Diagnosis and therapy in neuromuscular disorders: diagnosis and new treatments in mitochondrial diseases. JNNP 2009; 80:943-953.
- Chinnery PF, Elliott C, Green GR, et al. The spectrum of hearing loss due to mitochondrial DNA defects. Brain 2000; 123:82-92.
- Mattman A, O'Riley M, Waters PJ, et al. Diagnosis and management of patients with mitochondrial disease. BC Med J 2011; 53:177-182.
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