Motor neurone disease (MND): potential CSF biomarkers

Evidence-based neurology checklist on motor neurone disease (mnd): potential csf biomarkers: Potential biomarkers elevated in the CSF Anti-ganglioside antibodies Basic fibroblast growth factor (bFGF) Chitotriosidase 1 (CHIT 1) Chromogranin A (CgA) Cystacin C Ferritin heavy chain (FHC) Ferritin…

Potential biomarkers elevated in the CSF

  • Anti-ganglioside antibodies
  • Basic fibroblast growth factor (bFGF)
  • Chitotriosidase 1 (CHIT 1)
  • Chromogranin A (CgA)
  • Cystacin C
  • Ferritin heavy chain (FHC)
  • Ferritin light chain (FLC)
  • Flt3 ligand
  • Homocysteine
  • Interferon γ (IFN-γ): may be a marker of progression
  • Insulin-like growth factor 1 (IGF 1)
  • Interleukin 12, 15, 17, and 23
  • Matric metaloproteinases (MMPs)
  • MIP 1α; may be neuroprotective
  • Monocyte chemotactic protein 1 (MCP 1)
  • Neurofilaments
  • Nitrate
  • Prostaglandin E2 (PGE2)
  • Tau
  • Vascular endothelial growth factor (VEGF)

Potential biomarkers reduced in the CSF

References

  1. Niebroj-Dobosz I, Jamrozik Z, Janik P, Hausmanowa-Petrusewicz I, Kwieciński H. Anti-neural antibodies in serum and cerebrospinal fluid of amyotrophic lateral sclerosis (ALS) patients. Acta Neurol Scand 1999; 100:238-243.
  2. Gong Z, Gao L, Guo J, Lu Y, Zang D. bFGF in the CSF and serum of sALS patients. Acta Neurol Scand 2015; 132:171-178. 
  3. Varghese AM, Sharma A, Mishra P, et al. Chitotriosidase-a putative biomarker for sporadic amyotrophic lateral sclerosis. Clin Proteomics 2013; 10:19.
  4. Kaiserova M, Grambalova Z, Otruba P, et al. Cerebrospinal fluid levels of chromogranin A and phosphorylated neurofilament heavy chain are elevated in amyotrophic lateral sclerosis. Acta Neurol Scand 2017; doi: 10.1111/ane.12735 (Epub ahead of print).
  5. Tsuji-Akimoto S, Yabe I, Niino M, Kikuchi S, Sasaki H. Cystatin C in cerebrospinal fluid as a biomarker of ALS. Neurosci Lett 2009; 452:52-55.
  6. And 23 more. Subscribe to see the full list

Related checklists

Loading...