Motor neurone disease (MND): prognostic features

Survival

• The median survival from symptom onset is 32 months
• The median survival from diagnosis is 19 months
• The 5-year survival after diagnosis is 7%

Predictors of longer survival

Poor prognostic clinical factors

Poor prognostic laboratory factors: serum

Poor prognostic laboratory factors: others

Good prognostic factors

MND staging systems

References

1. del Aguila MA, Longstreth WT, McGuire V, Koepsell TD, van Belle G. Prognosis in amyotrophic lateral sclerosis: a population-based study. Neurology 2003; 60:813-819.
2. Pupillo E, Messina P, Logroscino G, Beghi E; SLALOM Group. Long-term survival in amyotrophic lateral sclerosis: a population-based study. Ann Neurol 2014; 75:287-297.
3. Fujimura-Kiyono C, Kimura F, Ishida S, et al. Onset and spreading patterns of lower motor neuron involvements predict survival in sporadic amyotrophic lateral sclerosis. JNNP 2011; 82:1244-1249.
4. Wijesekera LC, Mathers S, Talman P, et al. Natural history and clinical features of the flail arm and flail leg ALS variants. Neurology 2009; 72:1087-1094.
5. Paganoni S, Zhang M, Quiroz Zarate A, et al. Uric acid levels predict survival in men with amyotrophic lateral sclerosis. J Neurol 2012; 259:1923-1928.
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Related checklists

• Motor neurone disease (MND): neuromuscular features
• Motor neurone disease (MND): other features
• Motor neurone disease (MND): diagnostic criteria
• Motor neurone disease (MND): differential diagnosis