Motor neurone disease (MND): systemic symptomatic treatments
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Motor neurone disease (MND): systemic symptomatic treatments. Atropine tablets/liquid: 0.25–0.75 mg three times daily, Atropine eye drops sublingually.
Sialorrhoea and drooling
- Atropine tablets/liquid: 0.25–0.75 mg three times daily
- Atropine eye drops sublingually
- Benztropine tablets/liquid
- Benzhexol tablets
- Hyoscine tablets or transdermal patches
- Amitriptyline tablets or liquid
- Glycopyrrolate liquid: subcutaneous, intramuscular, or via gastrostomy
- Home suction device
- Carbocisteine for thick sputum: 250–750 mg syrup tds orally or via gastrostomy
Refractory sialorrhoea and drooling
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Dyspnoea
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Laryngospasm
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Constipation
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Other symptomatic treatments
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References
- Leigh PN, Abrahams S, Al-Chalabi A, et al. The management of motor neurone disease. JNNP 2003; 74(Suppl IV):iv32-iv47.
- Miller RG, Jackson CE, Kasarskis EJ, et al. Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: drug, nutritional, and respiratory therapies. Neurology 2009; 73:1228-1226.
- Wood-Allum C, Shaw PJ. Motor neurone disease: a practical update on diagnosis and management. Clin Med 2010; 10:252-258.
- Radunović A, Mitsumoto H, Leigh PN. Clinical care of patients with amyotrophic lateral sclerosis. Lancet Neurol 2007; 6:913-925.
- The Excerpta Medica MND Advisory Group. Guidelines for the management of motor neurone disease (MND). June 1999.
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