Myasthenia gravis (MG) AChR antibodies
Evidence-based neurology checklist on myasthenia gravis (mg) achr antibodies: Routine AChR antibody test This is positive in 85% of generalised MG Levels do not correlate with disease severity AChR antibody radioimmunoprecipitation assay (RIPA) Clustered AChR antibody test Causes of false positive…
Routine AChR antibody test
- This is positive in 85% of generalised MG
- Levels do not correlate with disease severity
AChR antibody radioimmunoprecipitation assay (RIPA)
Clustered AChR antibody test
Causes of false positive AChR antibody titers
Causes of false negative AChR antibody test
References
- Skeie GO, Apostolski S, Evoli A, et al. Guidelines for treatment of autoimmune neuromuscular transmission disorders. Eur J Neurol 2010; 17:893-902.
- Thanvi BR, Lo TCN. Update on myasthenia gravis. Postgrad Med J 2004; 80:690–700.
- Jayam Trouth A, Dabi A, Solieman N, Kurukumbi M, Kalyanam J. Myasthenia gravis: a review. Autoimmune Dis 2012; 2012:874680.
- Zara P, Chessa P, Deiana GA, et al. Risk of false acetylcholine receptor autoantibody positivity by radioimmunoprecipitation assay in clinical practice. Neurology 2025; 104:e213498.
- Zhao G, Wang X, Yu X, Zhang X, Guan Y, Jiang J. Clinical application of clustered-AChR for the detection of SNMG. Sci Rep 2015; 5:10193.
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