Narcolepsy: investigations
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Narcolepsy: investigations. HLA-DR2, HLA-DQB1*0602. Fully referenced neurology checklist.
HLA associations
- HLA-DR2
- HLA-DQB1*0602
Cerebrospinal fluid (CSF) hypocretin: values
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Cerebrospinal fluid (CSF) hypocretin: causes of intermediate low levels
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Multiple sleep latency test (MSLT)
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Aquaporin 4 antibodies
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References
- Fontana A, Gast H, Reith W, et al. Narcolepsy: autoimmunity, effector T cell activation due to infection, or T cell independent major histocompatibility complex class II induced neuronal loss? Brain 2010; 133:1300-1311.
- Ebrahim IO, Sharief MK, de Lacy S, et al. Hypocretin (orexin) deficiency in narcolepsy and primary hypersomnia. JNNP 2003; 74:127-130.
- Mignot E, Lammers GJ, Ripley B, et al. The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnia. Arch Neurol 2002; 59:1553-1562.
- Biscarini F, Vandi S, Neccia G, et al. To diagnose Narcolepsy type 1 after a negative multiple sleep latency test: the contribution of systematic hypocretin measurement. Sleep 2026 (Online ahead of print).
- Billiard M, Bassetti C, Dauvilliers Y, et al; EFNS Task Force. EFNS guidelines on management of narcolepsy. Eur J Neurol 2006; 13:1035-1048.
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