Neurolymphomatosis

Evidence-based neurology checklist on neurolymphomatosis: Pathology This is invasion of nerves by aggressive NHL It is usually caused by diffuse large cell B cell lymphoma (DLCBL) It may occur in the setting of Waldenstrom’s macroglobulinaemia Classification Clinical features Differential…

Pathology

  • This is invasion of nerves by aggressive NHL
  • It is usually caused by diffuse large cell B cell lymphoma (DLCBL)
  • It may occur in the setting of Waldenstrom’s macroglobulinaemia

Classification

Clinical features

Differential diagnosis

Investigations

Treatment

Prognosis

References

  1. Baehring JM, Batchelor TT. Diagnosis and management of neurolymphomatosis. Cancer J 2012; 18:463-468.
  2. Lahoria R, Dyck PJ, Macon WR, et al. Neurolymphomatosis: a report of 2 cases representing opposite ends of the clinical spectrum. Muscle Nerve 2015; 52:449-454.
  3. Keddie S, Nagendran A, Cox T, et al. Peripheral nerve neurolymphomatosis: clinical features, treatment and outcomes. Muscle Nerve 2020 (Online ahead of print).
  4. Cox BC, Mauermann ML, Theel ES, Toledano M. Clinical Reasoning: Multifocal neuropathies in a patient with Waldenstrom macroglobulinemia and prior borreliosis. Neurology 2020; 95:44-48.
  5. Skolka MP, Suanprasert N, Martinez-Thompson JM, et al. Neurologic clinical, electrophysiologic, and pathologic characteristics of primary vs secondary neurolymphomatosis. Neurology 2024; 103:e209777. 
  6. And 8 more. Subscribe to see the full list

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