Onchocerciasis: seizure syndromes

Evidence-based neurology checklist on onchocerciasis: seizure syndromes: Onchocerciasis associated epilepsy (OAE) There is a clustering near rapid-flowing black-fly-infested rivers The onset age is between 3 and 18 years It presents with tonic-clonic, absence, or myoclonic seizures Nodding…

Onchocerciasis associated epilepsy (OAE)

  • There is a clustering near rapid-flowing black-fly-infested rivers 
  • The onset age is between 3 and 18 years
  • It presents with tonic-clonic, absence, or myoclonic seizures

Nodding syndrome

Nakalanga syndrome: features

References

  1. Colebunders R, Nelson Siewe FJ, Hotterbeekx A. Onchocerciasis-associated epilepsy, an additional reason for strengthening onchocerciasis elimination programs. Trends Parasitol 2018; 34:208-216.
  2. Johnson TP, Tyagi R, Lee PR, et al. Nodding syndrome may be an autoimmune reaction to the parasitic worm Onchocerca volvulus. Sci Transl Med 2017; 9(377).
  3. Duke BO, Vincelette J, Moore PJ. Microfilariae in the cerebrospinal fluid, and neurological complications, during treatment of onchocerciasis with diethylcarbamazine. Tropenmed Parasitol 1976; 27:123-132.
  4. Winkler AS, Wallner B, Friedrich K, et al. A longitudinal study on nodding syndrome-a new African epilepsy disorder. Epilepsia 2014; 55:86-93.
  5. Kipp W, Burnham G, Bamuhiiga J, Leichsenring M. The Nakalanga syndrome in Kabarole District, Western Uganda. Am J Trop Med Hyg 1996; 54:80-83.
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