Opsoclonus myoclonus syndrome (OMS): clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Opsoclonus myoclonus syndrome (OMS): clinical features. This is a chaotic multidirectional eye movement disorder (saccadomania).
Opsoclonus
- This is a chaotic multidirectional eye movement disorder (saccadomania)
- The movements are conjugate or semi-conjugate
- They are startle and stimulus sensitive
- They may occur in bouts
- They may manifest with or without myoclonus
- The symptoms improve when the eyes are shut
- They also improve in sleep
- They are worsened with eye movements and fixation
- They may persist in coma
- There may be associated oscillopsia
- There is no associated diplopia
Myoclonus
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Other features
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Differential diagnosis of opsoclonus
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Synonym
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References
- Sahu JK, Prasad K. The opsoclonus myoclonus syndrome. Pract Neurol 2011; 11:160-166.
- Pranzatelli MR. The neurobiology of the opsoclonus-myoclonus syndrome. Clin Neuropharmacol 1992; 15:186-228.
- Bataller L, Graus F, Saiz A, et al. Clinical outcome in adult onset idiopathic or paraneoplastic opsoclonus-myoclonus. Brain 2001; 124:437-443.
- Brunklaus A, Pohl K, Zuberi SM, de Sousa C. Outcome and prognostic features in opsoclonus-myoclonus syndrome from infancy to adult life. Pediatrics 2011; 128:e388-e394.
