Other familial pituitary adenoma syndromes
Evidence-based neurology checklist on other familial pituitary adenoma syndromes: Multiple endocrine neoplasia type 1 (MEN1) This is caused by MEN1 activating gene mutations The gene codes for menin It manifests with: Primary hyperparathyroidism Pancreatic neuroendocrine tumours Pituitary…
Multiple endocrine neoplasia type 1 (MEN1)
- This is caused by MEN1 activating gene mutations
- The gene codes for menin
- It manifests with:
- Primary hyperparathyroidism
- Pancreatic neuroendocrine tumours
- Pituitary adenomas: especially prolactinomas
Multiple endocrine neoplasia type 4 (MEN4)
McCune Albright syndrome
Familial isolated pituitary adenomas (FIPA)
Pituitary blastoma with Cushing’s syndrome
Xq26.3 microdeletions: manifestations
MEN syndromes without pituitary adenomas: MEN2
MEN syndromes without pituitary adenomas: MEN3
Carney complex
References
- Schernthaner-Reiter MH, Trivellin G, Stratakis CA. MEN1, MEN4, and Carney complex: pathology and molecular genetics. Neuroendocrinology 2016;1 03:18-31.
- Vandeva S, Vasilev V, Vroonen L, et al. Familial pituitary adenomas. Ann Endocrinol (Paris) 2010; 71:479-485.
- Arafah BM, Nasrallah MP. Pituitary tumors: pathophysiology, clinical manifestations and management. Endocr Relat Cancer 2001; 8:287-305.
- Levy A. Pituitary disease: presentation, diagnosis, and management. JNNP 2004; 75(Suppl 3):iii47-iii52.
- Thakker RV. Multiple endocrine neoplasia type 1 (MEN1) and type 4 (MEN4). Mol Cell Endocrinol 2014; 386:2-15.
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