Paraneoplastic motor neurone disease (MND)

Evidence-based neurology checklist on paraneoplastic motor neurone disease (mnd): Clinical features The onset is subacute It predominantly causes a lower motor neuron syndrome It usually presents with asymmetric upper limb involvement There may be associated upper motor neuron features There may…

Clinical features

  • The onset is subacute
  • It predominantly causes a lower motor neuron syndrome
  • It usually presents with asymmetric upper limb involvement
  • There may be associated upper motor neuron features
  • There may be associated sensory neuronopathy

Associated malignancies

Paraneoplastic antibody tests

Cerebrospinal fluid (CSF) analysis

Other investigations

Treatment

References

  1. Mélé N, Berzero G, Maisonobe T, et al. Motor neuron disease of paraneoplastic origin: a rare but treatable condition. J Neurol 2018; 265:1590-1599.
  2. Diamanti L, Quaquarini E, Berzero G, et al. Lower motor neuron syndrome in a patient with HER2-positive metastatic breast cancer: a case report and review of the literature. Clin Neurol Neurosurg 2018; 172:141-142. 
  3. Sadot E, Carluer L, Corcia P, Delozier Y, Levy C, Viader F. Breast cancer and motor neuron disease: clinical study of seven cases. Amyotroph Lateral Scler 2007; 8:288-291.
  4. Forsyth PA, Dalmau J, Graus F, Cwik V, Rosenblum MK, Posner JB. Motor neuron syndromes in cancer patients. Ann Neurol 1997; 41:722-730.
  5. Diard-Detoeuf C, Dangoumau A, Limousin N, et al. Association of a paraneoplastic motor neuron disease with anti-Ri antibodies and a novel SOD1 I18del mutation. J Neurol Sci 2014; 337:212-214.
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