Paraproteinaemia classifications

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Paraproteinaemia classifications. This is a premalignant clonal disorder. Fully referenced neurology checklist.

Monoclonal gammopathy of uncertain significance (MGUS)

  • This is a premalignant clonal disorder
  • There is a monoclonal protein (M-protein) produced by abnormal plasma or B-cells

Monoclonal gammopathy of clinical significance (MGUS)

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Malignant paraproteinaemias

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Cutaneous MGCS types

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Acronyms

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References

  1. Cho H. Diagnosis and management of monoclonal gammopathy of clinical significance. Blood Res 2022; 57(S1):20-26. 
  2. Liu A, Suozzi K, Hwang DY, Moeller JJ, Lazova R, DiCapua D. Dermatoneuro syndrome: a full recovery after a second episode. Neurol Clin Pract 2016; 6:e27-e29. 
  3. Rey JB, Luria RB. Treatment of scleromyxedema and the dermatoneuro syndrome with intravenous immunoglobulin. J Am Acad Dermatol 2009; 60:1037-1041.
  4. Bhoyrul B, Mughal AA, Paulus J, Salamat A, Howarth S. Does dermatoneuro syndrome have a viral aetiology? Clin Exp Dermatol 2016; 41:53-56.
  5. Druey KM, Parikh SM. Idiopathic systemic capillary leak syndrome (Clarkson disease). J Allergy Clin Immunol 2017; 140:663-670.

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