Parkinson's disease (PD): timeline and progression

Evidence-based neurology checklist on parkinson's disease (pd): timeline and progression: Prodrome: 20 years before motor phase Hyposmia Constipation Bladder symptoms Prodrome: 10 years before motor phase Clinical onset Progression: 5 years after onset Progression: 10 years after onset…

Prodrome: 20 years before motor phase

  • Hyposmia
  • Constipation
  • Bladder symptoms

Prodrome: 10 years before motor phase

Clinical onset

Progression: 5 years after onset

Progression: 10 years after onset

Progression: 15 years after onset

Progression: 20 years after onset

Progression course

References

  1. Hawkes CH, Tredici KD, Braak H. A timeline for Parkinson's disease. Parkinsonism Relat Disord 2010; 16:79-84.
  2. Maetzler W, Liepelt I, Berg D. Progression of Parkinson’s disease in the clinical phase: potential markers. Lancet Neurol 2009; 8:1158-1171.
  3. Poewe W. The natural history of Parkinson's disease. J Neurol 2006; 253 (Suppl 7):VII/2-VII/6.
  4. Verschuur CVM, Suwijn SR, Boel JA, et al; LEAP Study Group. Randomized delayed-start trial of levodopa in Parkinson's disease. N Engl J Med 2019; 380:315-324.
  5. And 0 more. Subscribe to see the full list

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