Pregnancy and neuromyelitis optica (NMO)

Evidence-based neurology checklist on pregnancy and neuromyelitis optica (nmo): Effect of pregnancy on NMO There is an increased the risk of NMO relapses in pregnancy There is also an increased risk of relapses post-partum and post-abortion Pregnancy worsens disability in neuromyelitis optica…

Effect of pregnancy on NMO

  • There is an increased the risk of NMO relapses in pregnancy
  • There is also an increased risk of relapses post-partum and post-abortion
  • Pregnancy worsens disability in neuromyelitis optica (NMO)

Effect of NMO on pregnancy

Risk factors for increased NMO relapses in pregnancy

Treatment of NMO in pregnancy: safe drugs

References

  1. Klawiter EC, Bove R, Elsone L, et al. High risk of postpartum relapses in neuromyelitis optica spectrum disorder. Neurology 2017; 89:2238-2244.
  2. Tong Y, Liu J, Yang T, et al. Influences of pregnancy on neuromyelitis optica spectrum disorders and multiple sclerosis. Mult Scler Relat Disord 2018; 25:61-65.
  3. Borisow N, Hellwig K, Paul F. Neuromyelitis optica spectrum disorders and pregnancy: relapse-preventive measures and personalized treatment strategies. EPMA J 2018; 9:249-256. 
  4. Mao-Draayer Y, Thiel S, Mills EA, et al. Neuromyelitis optica spectrum disorders and pregnancy: therapeutic considerations. Nat Rev Neurol 2020; 16:154-170.
  5. Wang L, Zhou L, ZhangBao J, et al. Neuromyelitis optica spectrum disorder: pregnancy-related attack and predictive risk factors. JNNP 2020; 92:53-61.
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