Progressive multifocal leukoencephalopathy (PML): management

Evidence-based neurology checklist on progressive multifocal leukoencephalopathy (pml): management: Pre-Natalizumab assessments Serum anti JC virus antibody Magnetic resonance imaging (MRI) Urine JC virus DNA polymerase chain reaction (PCR) PML monitoring on Natalizumab therapy Treatment…

Pre-Natalizumab assessments

  • Serum anti JC virus antibody
  • Magnetic resonance imaging (MRI)
  • Urine JC virus DNA polymerase chain reaction (PCR)

PML monitoring on Natalizumab therapy

Treatment guidelines in suspected PML

Treatment of PML

Re-starting treatment in suspected PML

Investigational treatments

Acronym

References

  1. Hunt D, Giovannoni G. Natalizumab-associated progressive multifocal leucoencephalopathy: a practical approach to risk profiling and monitoring. Pract Neurol 2012; 12:25-35.
  2. Clifford DB, DeLuca A, Simpson DM, Arendt G, Giovannoni G, Nath A. Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: lessons from 28 cases. Lancet Neurol 2010; 9:438-446.
  3. Warnke C, Menge T, Hartung H-P, et al. Natalizumab and progressive multifocal leukoencephalopathy. Arch Neurol 2010; 67:923-930.
  4. Sorenson PS, Bertolotto A, Edan G, et al. Risk stratification for progressive multifocal leukoencephalopathy in patients rated with natalizumab. Mult Scler 2012; 18:143-152.
  5. McGuigan C, Craner M, Guadagno J, et al. Stratification and monitoring of natalizumab-associated progressive multifocal leukoencephalopathy risk: recommendations from an expert group. JNNP 2016; 87:117-125.
  6. And 10 more. Subscribe to see the full list

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