Rosai-Dorfman disease (RDD): pathology
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Rosai-Dorfman disease (RDD): pathology. RDD is a non-Langerhans cell reactive histiocytic disorder. Fully referenced neurology checklist.
Description
- RDD is a non-Langerhans cell reactive histiocytic disorder
- It is a non-neoplastic lymphoproliferative disease
- It primarily affects the lymph nodes
- Extranodal involvement occurs in 50% of cases
Pathological features
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Reported associated gene mutations
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Associated autoimmune disorders
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Associated neoplastic disorders
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Possible associated viral disorders
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Synonyms
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References
- Qin G, Ye J, Lan S, et al. Rosai-Dorfman disease with spinal and multiple intracranial involvement: a case report and literature review. Br J Neurosurg 2019; 18:1-5.
- Gilani K, Kuntz S, Munoz DG, Schneider R. Pearls & Oy-sters: Rosai-Dorfman disease of the central nervous system. Neurology 2021 (Online ahead of print).
- Varrassi M, Corridore A, Tommasino E, et al. MR imaging of cerebral involvement of Rosai-Dorfman disease: a single-centre experience with review of the literature. Radiol Med 2021; 126:89-98.
- Abla O, Jacobsen E, Picarsic J, et al. Consensus recommendations for the diagnosis and clinical management of Rosai-Dorfman-Destombes disease. Blood 2018; 131:2877-2890.
- Baassiri W, Moussalem CK, Massaad E, Zeidan YH, Darwish H. Craniocervical Rosai-Dorfman Disease involving the vertebral artery: case report and literature review. World Neurosurg 2020; 133:69-73.
