Sleeping sickness: central features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Sleeping sickness: central features. This is the early hemolymphatic stage. Fully referenced neurology checklist.
Stage 1 sleeping sickness
- This is the early hemolymphatic stage
- Trypomastigota multiply in blood and lymph nodes
- The parasites are also in the spleen, liver, skin, heart, eyes, and endocrine system
Stage 2 sleeping sickness
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Sleep disorders
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Psychiatric features
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Neuromuscular features
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Movement disorders
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Primitive reflexes
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Other central features
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Differential diagnosis
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Synonyms
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References
- Dzikowiec M, Góralska K, Błaszkowska J. Neuroinvasions caused by parasites. Ann Parasitol 2017; 63:243–253.
- Malvy D, Chappuis F. Sleeping sickness. Clin Microbiol Infect 2011; 17:986-995.
- Ehrhardt S, Lippert U, Burchard GD, Sudeck H. Orchitis as an unusual manifestation of human African trypanosomiasis. J Infect 2006; 52:e31-e33.
- Stich A, Abel PM, Krishna S. Human African trypanosomiasis. BMJ 2002; 325:203-206.
- Kennedy PG. Human African trypanosomiasis of the CNS: current issues and challenges. J Clin Invest 2004; 113:496-504.
