Sporadic late onset nemaline myopathy (SLONM)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Sporadic late onset nemaline myopathy (SLONM). SLOAN without monoclonal protein: this accounts for about 40% of cases.

Classification

  • SLOAN without monoclonal protein: this accounts for about 40% of cases
  • SLONM with monoclonal protein: this accounts for about 6o% of cases

General features

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Features of SLOAN with monoclonal protein

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Associations of SLOAN without monoclonal protein

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Magnetic resonance imaging (MRI) muscle: affected sites

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Treatments of SLONM with monoclonal gammopathy

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Acronym

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References

  1. Naddaf E, Milone M, Kansagra A, Buadi F, Kourelis T. Sporadic late-onset nemaline myopathy: clinical spectrum, survival, and treatment outcomes. Neurology 2019; e298-e305.
  2. Paramalingam S, Dyke JM, Nossent JC. Sporadic late onset nemaline myopathy (SLONM) in an adult presenting with progressive muscle weakness. Eur J Rheumatol 2018; 6:1-3. 
  3. Uruha A, Benveniste O. Sporadic late-onset nemaline myopathy with monoclonal gammopathy of undetermined significance. Curr Opin Neurol 2017; 30:457-463.
  4. Schnitzler LJ, Schreckenbach T, Nadaj-Pakleza A, et al. Sporadic late-onset nemaline myopathy: clinico-pathological characteristics and review of 76 cases. Orphanet J Rare Dis 2017; 12:86.
  5. Kanamori T, Kusumoto S, Okita K, et al. Sporadic late-onset nemaline myopathy with monoclonal gammopathy of undetermined significance mimicking POEMS syndrome. Rinsho Ketsueki 2018; 59:161-166.
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