Statin induced peripheral neuropathy (PN)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Statin induced peripheral neuropathy (PN). The strength of the risk of neuropathy with Statins is inconclusive. Fully referenced neurology checklist.
Risk of neuropathy with Statins
- The strength of the risk of neuropathy with Statins is inconclusive
- Most studies and reviews reported no risk or only a weak, minimal, or modest risk
- One major case-control study reported a significant risk
Statin axonal neuropathy
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Other statin neuropathy types
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Differential diagnosis
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References
- Warendorf JK, Vrancken AFJE, van Eijk RPA, Visser NA, van den Berg LH, Notermans NC. Statins do not increase risk of polyneuropathy: a case-control study and literature review. Neurology 2019; 92:e2136-e2144.
- Phan T, McLeod JG, Pollard JD, Peiris O, Rohan A, Halpern J-P. Peripheral neuropathy associated with simvastatin. JNNP 1995; 58:635-628.
- Jeppesen U, Gaist D, Smith T, Sindrup SH. Statins and peripheral neuropathy. Eur J Clin Pharmacol 1999; 54:835-838.
- Tierney EF, Thurman DJ, Beckles GL, Cadwell BL. Association of statin use with peripheral neuropathy in the U.S. population 40 years of age or older. J Diabetes 2013; 5:207-215.
- Corrao G, Zambon A, Bertu L, Botteri E, Leoni O, Contiero P. Lipid lowering drugs prescription and the risk of peripheral neuropathy: an exploratory case-control study using automated databases. J Epidemiol Community Health 2000; 58:1047-1051.
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