Stiff person syndrome (SPS): treatments
Evidence-based neurology checklist on stiff person syndrome (sps): treatments: Spasticity treatment: GABA-A receptor binding drugs Diazepam 5mg bid and increase to 10mg bid or tid Clonazepam 0.5-5mg Spasticity treatment: others Spasticity treatment: rarely used Treatment of respiratory crisis…
Spasticity treatment: GABA-A receptor binding drugs
- Diazepam 5mg bid and increase to 10mg bid or tid
- Clonazepam 0.5-5mg
Spasticity treatment: others
Spasticity treatment: rarely used
Treatment of respiratory crisis
Effective immunosuppression
Less effective long-term immunosuppression
Other treatments
References
- Dalakas MC. Therapies in stiff-person syndrome: advances and future prospects based on disease pathophysiology. Neurol Neuroimmunol Neuroinflamm 2023; 10:e200109.
- Cosentino G, Romano M, Algeri M, Brighina F, Alfonsi E, Tassorelli C, Crescimanno G. Intranasal midazolam for treating acute respiratory crises in a woman with stiff person syndrome. Neurol Neuroimmunol Neuroinflamm 2020; 7:e715.
- Kass-Iliyya L, Snowden JA, Thorpe A, et al. Autologous haematopoietic stem cell transplantation for refractory stiff-person syndrome: the UK experience. J Neurol 2020 (Online ahead of print).
- Celli SI, Nash R, Money KM, et al. Successful autologous hematopoietic stem cell transplant in glycine receptor antibody-positive stiff person syndrome: a case report. Neurol Neuroimmunol Neuroinflamm 2024; 11:e200197.
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