Topiramate
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Topiramate. Topiramate blocks voltage gated sodium channels. It augments GABAA receptors. Fully referenced neurology checklist.
Mechanism of action
- Topiramate blocks voltage gated sodium channels
- It augments GABAA receptors
- It inhibits carbonic anhydrase
Dosing
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Indications
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Contraindications and precautions
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Neuropsychiatric side effects
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Systemic side effects
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Teratogenicity
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References
- Goldenberg MM. Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment. P T 2010; 35:392-415.
- Faught E. Topiramate in the treatment of partial and generalized epilepsy. Neuropsychiatr Dis Treat 2007; 3:811-821.
- Arroyo S, Dodson WE, Privitera MD, et al; EPMN-106/INT-28 Investigators. Randomized dose-controlled study of topiramate as first-line therapy in epilepsy. Acta Neurol Scand 2005; 112:214-222.
- Sommer BR, Mitchell EL, Wroolie TE. Topiramate: Effects on cognition in patients with epilepsy, migraine headache and obesity. Ther Adv Neurol Disord 2013; 6:211-227.
- Gopalakrishna M, Odayappan A, Srinivasan K, Rengaraj V. A case series of topiramate-induced angle closure crisis-an ophthalmic emergency. Cephalalgia 2020; 40:1389-1393.
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