Hereditary spastic paraplegia (HSP): differential diagnosis

Neurodegenerative differentials

• Dopa-responsive dystonia (DRD)
• Motor neurone disease (MND): primary lateral sclerosis (PLS)
• Spinocerebellar ataxia (SCA)
• Friedreich’s ataxia (FA)

Inflammatory and infective differentials

Nutritional and metabolic differentials

Structural and vascular differentials

Other differentials

Terminology

References

1. Salinas S, Proukakis C, Crosby A, Warner TT. Hereditary spastic paraplegia: clinical features and pathogenetic mechanisms. Lancet Neurol 2008; 7:1127-1138.
2. Miller DH, Leary SM. Primary-progressive multiple sclerosis. Lancet Neurol 2007; 6:903-912.
3. Warner T. Hereditary spastic paraplegia. ACNR 2007; 6: 16-17.
4. Hensiek A, Kirker S, Reid E. Diagnosis, investigation and management of hereditary spastic paraplegias in the era of next-generation sequencing. J Neurol 2015; 262:1601-1612.
5. Fukushima T, Shirota M, Waragai M, et al. Spinal endoscopic biopsy in the diagnosis of central nervous system neurosarcoidosis. JNNP 2006; 77:702.
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Related checklists

• Hereditary spastic paraplegia (HSP): summary of key features
• Hereditary spastic paraplegia (HSP): clinical features
• Hereditary spastic paraplegia (HSP): radiological features
• Hereditary spastic paraplegia (HSP): investigations