Neurosyphilis: clinical features

Evidence-based neurology checklist on neurosyphilis: clinical features: Clinical phenotypes Asymptomatic neurosyphilis: there is only abnormal cerebrospinal fluid (CSF) Acute or subacute myelopathy: this is frequently in the thoracolumbar region Tabes dorsalis General paresis of the insane (GPI)…

Clinical phenotypes

  • Asymptomatic neurosyphilis: there is only abnormal cerebrospinal fluid (CSF)
  • Acute or subacute myelopathy: this is frequently in the thoracolumbar region
  • Tabes dorsalis
  • General paresis of the insane (GPI)
  • Taboparesis
  • Vascular-stroke
  • Meningovascular syphilis
  • Optic neuritis (ON)

Tabes dorsalis: features

General paresis of the insane (GPI): features

Meningovascular syphilis: types

Syphilis in association with HIV

Other presentations of neurosyphilis

Differential diagnosis

References

  1. Carr J. Neurosyphilis. Pract Neurol 2003; 3:328-341.
  2. Kingston M, French P, Goh B, et al. UK National guidelines on the management of syphilis 2008. Int J STD AIDS 2008; 19:729-740.
  3. Osman C, Clark TW. Tabes dorsalis and Argyll Robertson pupils. N Engl J Med 2016; 375:e40. 
  4. Hobbs E, Vera JH, Marks M, Barritt AW, Ridha BH, Lawrence D. Neurosyphilis in patients with HIV. Pract Neurol 2018; 18:211-218. 
  5. Shah BB, Lang AE. Acquired neurosyphilis presenting as movement disorders. Mov Disord 2012; 27:690-695.
  6. And 9 more. Subscribe to see the full list

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