Anti MGluR1 autoimmune encephalitis
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Anti MGluR1 autoimmune encephalitis. This is an autoimmune encephalitis. It has a predilection for the cerebellum. Fully referenced neurology checklist.
Pathology
- This is an autoimmune encephalitis
- It has a predilection for the cerebellum
- It may be paraneoplastic
- It presents as a subacute cerebellar syndrome
Clinical features
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Associated features
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Investigations
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Outcome
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Synonym
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References
- Jarius S, Wildemann B. 'Medusa-head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII. J Neuroinflammation 2015; 12:166.
- Lopez-Chiriboga AS, Komorowski L, Kümpfel T, et al. Metabotropic glutamate receptor type 1 autoimmunity: Clinical features and treatment outcomes. Neurology 2016; 86:1009-1013.
- Marignier R, Chenevier F, Rogemond V, et al. Metabotropic glutamate receptor type 1 autoantibody-associated cerebellitis: a primary autoimmune disease? Arch Neurol 2010; 67:627-630.
- Spatola M, Petit Pedrol M, Maudes E et al. Clinical features, prognostic factors, and antibody effects in anti-mGluR1 encephalitis. Neurology 2020; 95:e3012-e3025.
- Khojah O, Makkawi S, Alghamdi S. Anti-mGluR1 encephalitis: case illustration and systematic review. Front Neurol 2023; 14:1142160.
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