Cerebrospinal fluid (CSF): lactate

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Cerebrospinal fluid (CSF): lactate. Collect sample in a fluoride bottle. Fully referenced neurology checklist.

CSF lactate analysis

  • Collect sample in a fluoride bottle
  • Use the least blood-stained CSF sample for analysis
  • Analyse the sample within one hour: freeze otherwise
  • Normal range is 1.2–2.1 mmol/L: it is up to 3mmol/L in neonates
  • Levels depend on CNS glycolysis and not on blood lactate level

Causes of high CSF lactate

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CSF lactate: differentiating value

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References

  1. Baheerathan A, Pitceathly RD, Curtis C, Davies NW. CSF lactate. Pract Neurol 2020; 20:320-323.

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