Cerebrospinal fluid (CSF): oligoclonal bands (OCB)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Cerebrospinal fluid (CSF): oligoclonal bands (OCB). Multiple sclerosis (MS), Systemic lupus erythematosus (SLE). Fully referenced neurology checklist.

Causes of positive CSF oligoclonal bands

  • Multiple sclerosis (MS)
  • Systemic lupus erythematosus (SLE)
  • Behcet's disease
  • Neurosarcoidosis
  • Harada's meningitis uveitis
  • Acute viral encephalitis
  • Acute bacterial meningitis
  • Subacute sclerosing pan encephalitis (SSPE)
  • Progressive rubella encephalitis
  • Neurosyphilis
  • HIV nervous system infection
  • Lyme neuroborreliosis
  • Brain tumours
  • Ataxia telangiectasia
  • Adrenoleukodystrophy (ALD)

Causes of matched oligoclonal bands

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Causes of negative oligoclonal bands

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References

  1. McLean BN, Luxton RW, Thompson EJ. A study of immunoglobulin G in the cerebrospinal fluid of 1007 patients with suspected neurological disease using isoelectric focusing and the log IgG-Index. Brain 1990; 113:1269-1289.
  2. Deisenhammer F, Bartos A, Egg R, Gilhus NE, et al. Guidelines on routine cerebrospinal fluid analysis. Report from an EFNS task force. Eur J Neurol 2006; 13:913-922.

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