Folate deficiency peripheral neuropathy (PN)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Folate deficiency peripheral neuropathy (PN). Alcoholism, Dietary deficiency, Drugs. Fully referenced neurology checklist.
Causes of folate deficiency
- Alcoholism
- Dietary deficiency
- Drugs
- Hereditary folate malabsorption (HFM)
- Also see Neurochecklist: “Cerebral folate deficiency: causes”
Clinical features
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Blood investigations
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Differential diagnosis
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Treatment
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References
- Koike H, Takahashi M, Ohyama K, et al. Clinicopathologic features of folate-deficiency neuropathy. Neurology 2015; 84:1026-1033.
- Manzoor M, Runcie J. Folate-responsive neuropathy: report of 10 cases. Br Med J 1976; 1:1176-1178.
- Steinschneider M, Sherbany A, Pavlakis S, Emerson R, Lovelace R, De Vivo DC. Congenital folate malabsorption: reversible clinical and neurophysiologic abnormalities. Neurology 1990; 40:1315.
- Shin DS, Mahadeo K, Min SH, et al. Identification of novel mutations in the proton-coupled folate transporter (PCFT-SLC46A1) associated with hereditary folate malabsorption. Mol Genet Metab 2011; 103:33-37.
