Methotrexate
Evidence-based neurology checklist on methotrexate: Precautions Use Folic acid 5mg daily 6 days a week Avoid Folic acid on the days Methotrexate is taken Institute male and female contraception Continue contraception for 3 months after stopping treatment Avoid live vaccines Annual influenza…
Precautions
- Use Folic acid 5mg daily 6 days a week
- Avoid Folic acid on the days Methotrexate is taken
- Institute male and female contraception
- Continue contraception for 3 months after stopping treatment
- Avoid live vaccines
- Annual influenza vaccinations
- Avoid excessive sun exposure
Contraindications
Baseline assessments
Assessments if chest X ray or TLCO are abnormal
Other assessments: liver biopsy
Monitoring blood tests
Monitoring frequency
Treatment of toxicity
Indications for stopping
References
- Chakravarty K, McDonald H, Pullar T, et al. BSR/BHPR guideline for disease-modifying anti-rheumatic drug (DMARD) therapy in consultation with the British Association of Dermatologists. Rheumatology 2008; 47:924-925.
- Ledingham J, Gullick N, Irving K, et al. BSR and BHPR guideline for the prescription and monitoring of non-biologic disease-modifying anti-rheumatic drugs. Rheumatology (Oxford) 2017; 56:865-868.
- Amato AA, Russell JA. Neuromuscular Disorders. McGraw Hill New York 2008 p711.
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