Neurosarcoidosis: CSF analysis
Evidence-based neurology checklist on neurosarcoidosis: csf analysis: Cerebrospinal fluid (CSF) features Protein: this is raised in a half of cases White cell count: there is Monocytic pleocytosis in >40% of cases Glucose: this is low in 20% of cases Oligoclonal bands (OCBs): these are present in…
Cerebrospinal fluid (CSF) features
- Protein: this is raised in a half of cases
- White cell count: there is Monocytic pleocytosis in >40% of cases
- Glucose: this is low in 20% of cases
- Oligoclonal bands (OCBs): these are present in 30% of cases
- Soluble interleukin 2 receptor (sIL-2R): levels are raised
- CD4:CD8 ratio: this is ≥ 5
- The CSF is normal in a third of cases
CSF risk factors for relapse
References
- Joseph FG, Scolding NJ. Neurosarcoidosis: a study of 30 new cases. JNNP 2009; 80:297-304.
- Hoitsma E, Faber CG, Drent M, Sharma OP. Neurosarcoidosis: a clinical dilemma. Lancet Neurol 2004; 3:397-407.
- Kidd DP. Sarcoidosis of the central nervous system: clinical features, imaging, and CSF results. J Neurol 2018; 265:1906-1915.
- Otto C, Wengert O, Unterwalder N, Meisel C, Ruprecht K. Analysis of soluble interleukin-2 receptor as CSF biomarker for neurosarcoidosis. Neurol Neuroimmunol Neuroinflamm 2020; 7:e725.
- Nordström S, Andersson B, Malmeström C. Cerebrospinal fluid CD4+ /CD8+ ratio in diagnosing neurosarcoidosis. Acta Neurol Scand 2020; 142:480-485.
- And 1 more. Subscribe to see the full list
