Neurosarcoidosis: MRI features

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Neurosarcoidosis: MRI features. Hydrocephalus, Non-specific white matter lesions, Mass lesions (granulomas). Fully referenced neurology checklist.

Typical brain MRI features

  • Hydrocephalus
  • Non-specific white matter lesions
  • Mass lesions (granulomas)
  • Meningeal enhancement
  • Perivascular radial enhancement
  • Cerebral atrophy
  • Cerebellar high signal changes
  • Optic nerve enhancement
  • Granulomatous angiitis
  • Cockscrew dilated medullary veins
  • Skull base lesions

Spinal MRI features: myelitis: types

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Spinal MRI features: others

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Venous sinus features

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Ischaemic lesions

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Haemorrhagic lesions

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Other lesions

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References

  1. Bathla G, Watal P, Gupta S, Nagpal P, Mohan S, Moritani T. Cerebrovascular manifestations of neurosarcoidosis: an underrecognized aspect of the imaging spectrum. Am J Neuroradiol 2018; 39:1194-1200. 
  2. Joseph FG, Scolding NJ. Neurosarcoidosis: a study of 30 new cases. JNNP 2009; 80:297-304.
  3. Hoitsma E, Faber CG, Drent M, Sharma OP. Neurosarcoidosis: a clinical dilemma. Lancet Neurol 2004; 3:397-407.
  4. Zajicek JP, Scolding NJ, Foster O, et al. Central nervous system sarcoidosis-diagnosis and management. QJM 1999; 92:103-117.
  5. Patrick N, Sosniuk M, Kapadia RK, Alikhani K, Fifi-Mah A, Hahn C. Characterizing persistent CNS MRI enhancement in patients with treated neurosarcoidosis. Neurol Clin Pract 2026; 16:e200653.
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