PARK2 genetic Parkinson's disease (PD)

Evidence-based neurology checklist on park2 genetic parkinson's disease (pd): Genetics This is caused by mutations in the PRKN (parkin) gene on chromosome 6q The gene product is ubiquitin The transmission is autosomal recessive Lewy bodies are often absent Epidemiological features Onset features…

Genetics

  • This is caused by mutations in the PRKN (parkin) gene on chromosome 6q
  • The gene product is ubiquitin
  • The transmission is autosomal recessive
  • Lewy bodies are often absent

Epidemiological features

Onset features

Treatment

References

  1. Takahashi H, Ohama E, Suzuki S, et al. Familial juvenile parkinsonism: clinical and pathologic study in a family. Neurology 1994; 44:437-441.
  2. Ishikawa A, Tsuji S. Clinical analysis of 17 patients in 12 Japanese families with autosomal-recessive type juvenile parkinsonism. Neurology 1996; 47:160-166.
  3. de Schipper LJ, Boon AJW, Munts AG. Foot drop dystonia resulting from parkin (PARK2) mutation. Move Disord Clin Pract 2015; 2:292-294.
  4. And 0 more. Subscribe to see the full list

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